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Medicago's H5N1 VLP vaccine demonstrates cross-reactivity against … FOXBusiness - 25 Jun 2008 … to protect against H5N1 pandemic influenza, using a transient expression system which produces recombinant vaccine antigens in non-transgenic plants. …

Promising Cancer Drug Target In Prostate Tumors Identified - Science Daily (press release)

Promising Cancer Drug Target In Prostate Tumors Identified Science Daily (press release) - 26 Jun 2008 In contrast, the "knockout" mice with no p110beta function remained free of prostate cancer even though the PTEN "brake" had been disabled. …

GM will not solve current food crisis - guardian.co.uk

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Old McDonald had a pharm - Salon

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Unexpected Finding Of Molecule's Dual Role In Mice May Open New … - Science Daily (press release)

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Notes on a Napkin hits on every parents fear. The protection of our children. And she gives you a phase to keep in your mind, perhaps forever, and for every occasion. Have we looked at Cinnamonspice before? This is a 4 day old one, but this is a blog

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Pitchforkmedia.com

Photo by Clayton Hauck/everyoneisfamous.com Pitchforkmedia.com, IL - 27 May 2008 This year's three-day Memorial Day weekend bonanza kicked off Saturday, May 24 with the likes of REM, Modest Mouse, MIA, the Breeders, the New Pornographers …

O'Keefe Receives Gruber Neuroscience Prize For Discovery Of Place … - Medical News Today (press release)

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Businesses think green - Indianapolis Star

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Prostate Cancer Chemoprevention By A Flavonoid Supplemented Diet … - Medical News Today (press release)

Prostate Cancer Chemoprevention By A Flavonoid Supplemented Diet … Medical News Today (press release), UK - 15 Jun 2008 The researchers hypothesized that oral consumption of these flavonoids reduces the incidence and progression of prostate cancer in a transgenic animal model …

Study hints at milk thistle's heart health benefits - NutraIngredients.com

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GTC Biotherapeutics to Webcast Annual Meeting on June 24, 2008 - WELT ONLINE

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NextBio Life Science Search Engine Advances Systems Biology … - Business Wire (press release)

NextBio Life Science Search Engine Advances Systems Biology … Business Wire (press release), CA - 9 Jun 2008 He will also update the life science community on the latest additions to NextBio s content base, including new human disease mutation and mouse knockout …

Show Review: REM at the United Center, Chicago, June 6, 2008 - Riverfront Times

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Deficiency of the NHE1 Gene Prevents Hypoxia-Induced Pulmonary … - RedOrbit

Deficiency of the NHE1 Gene Prevents Hypoxia-Induced Pulmonary … RedOrbit, TX - 3 Jun 2008 … pulmonary hypertension in hypoxia by NHE1 gene knockout mice, we analyzed mRNA and protein expression of RhoA, ROCK1, and ROCK2 in the mouse lungs. …

Old McDonald had a pharm - Salon

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Businesses think green Indianapolis Star, United States - 18 Jun 2008 Statewide, the Indiana Department of Environmental Management is spearheading an Ozone Knockout campaign to reduce carbon emissions. …

Letting the genome out of the bottle: Unraveling the genetics of … - TheHeart.Org

Letting the genome out of the bottle: Unraveling the genetics of … TheHeart.Org, NY - 3 hours ago … and different types of biologists tend to do that they will go and make knockout mice, do cell studies and structural studies, and the like. …

Caution On Stem Cell Therapy: Single Organs May Contain Several … - Science Daily (press release)

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Take a chill pill, T cell - Science News

Take a chill pill, T cell Science News - 19 Jun 2008 So the researchers tested how the knockout mouse immune system fared against a parasite called Toxoplasma gondii. The team used T. gondii because mice …

Interleukin 1 Signaling Plays A Critical Role In Prostate Development - Medical News Today (press release)

Interleukin 1 Signaling Plays A Critical Role In Prostate Development Medical News Today (press release), UK - 6 Jun 2008 IL-1R1 knockout mice showed significantly attenuated prostate development and decreased branching morphogenesis, as the ventral and dorsal-lateral lobes of …

VASCULAR DYSFUNCTION IN THE alpha-GALACTOSIDASE A-KNOCKOUT MOUSE IS AN ENDOTHELIAL CELL-, PLASMA MEMBRANE-BASED DEFECT.

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VASCULAR DYSFUNCTION IN THE alpha-GALACTOSIDASE A-KNOCKOUT MOUSE IS AN ENDOTHELIAL CELL-, PLASMA MEMBRANE-BASED DEFECT.

Clin Exp Pharmacol Physiol. 2008 Jun 18;

Authors: Park JL, Whitesall SE, D’Alecy LG, Shu L, Shayman JA

1. Fabry disease results from an X-linked mutation in the lysosomal alpha-galactosidase A (Gla) gene. Defective Gla results in multi-organ accumulation of neutral glycosphingolipids (GSLs), especially in the vascular endothelium, with the major GSL accumulated being globotriaosylceramide (Gb3). Excessive endothelial Gb3 accumulation is associated with increased thrombosis, atherogenesis and endothelial dysfunction. However, the mechanism(s) by which endothelial dysfunction occurs is unclear. The purpose of the present study was to further characterize the vasculopathy associated with a murine model of Fabry disease. 2. Vascular reactivity was performed in vessels from wild-type (Gla(+/0)) and Gla-knockout (Gla(-/0)) mice. Conscious blood pressure and heart rate were measured in Gla(+/0) and Gla(-/0) mice by telemetry. 3. The present study demonstrates that vascular smooth muscle (VSM) contractions to phenylephrine and serotonin, but not to U46619, were blunted in Gla(-/0) mice. Endothelium-dependent contraction and receptor-mediated endothelium-dependent relaxation to acetylcholine were significantly attenuated in vessels from Gla(-/0) mice. However, receptor-independent endothelium-dependent relaxation to the calcium ionophore ionomycin remained intact in vessels from Gla(-/0) mice. Furthermore, VSM reactivity was normal in aortas from Gla(-/0) mice in the absence of endothelium. These changes in vascular function were observed without changes in whole-animal blood pressure or heart rate. 4. These results suggest that the vasculopathy associated with Fabry disease is localized to the endothelium, despite the accumulation of GSLs throughout the vasculature.

PMID: 18565198 [PubMed - as supplied by publisher]

Animal identification and product traceability from the farm to … - OIE (press release)

Animal identification and product traceability from the farm to … OIE (press release), France - 12 Jun 2008 New technologies in animal production, such as animal cloning and transgenic animals, will create a need for additional arrangements to trace animals. …

SPEEDEL REPORTS ON DATA PUBLISHED AT HYPERTENSION 2008 MEDICAL … - ABN Newswire (press release)

SPEEDEL REPORTS ON DATA PUBLISHED AT HYPERTENSION 2008 MEDICAL … ABN Newswire (press release), Australia - 19 Jun 2008 The results of a further study with SPP301 (avosentan) in a mouse model of diabetic kidney disease demonstrate a strong anti-albuminuric efficacy of this …

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Unexpected Finding Of Molecule's Dual Role In Mice May Open New … Science Daily (press release) - 12 Jun 2008 What they did observe, however, was a dramatic decrease of cholesterol, triglycerides and free fatty acids in the XBP1-knockout mice compared with normal …

Businesses think green - Indianapolis Star

Businesses think green Indianapolis Star, United States - 18 Jun 2008 Statewide, the Indiana Department of Environmental Management is spearheading an Ozone Knockout campaign to reduce carbon emissions. …

Elixir Pharmaceuticals Researchers Publish New Data Validating … - FOXBusiness

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O'Keefe Receives Gruber Neuroscience Prize For Discovery Of Place … - Medical News Today (press release)

O'Keefe Receives Gruber Neuroscience Prize For Discovery Of Place … Medical News Today (press release), UK - 13 hours ago … aged but not in young transgenic mice which correlated with the animals' impairment on the memory task and also with plaque burden in the hippocampus, …

GTC Biotherapeutics to Webcast Annual Meeting on June 24, 2008 - WELT ONLINE

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Old McDonald had a pharm - Salon

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'Knockout mouse' maker Deltagen cuts Q1 loss - Bizjournals.com

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Prostate Cancer Chemoprevention By A Flavonoid Supplemented Diet … - Medical News Today (press release)

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Cre ERT2 mousecatalog is now available to the scientific community - Euronext (persbericht)

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Ten lines of transgenic mice secreting transmissible gastroenteritis coronavirus (TGEV) neutralizing recombinant monoclonal antibodies (rMAbs) into the milk were generated.

Transgenic Core Facility & Custom Surgical Services
The mission of the Loyola University Transgenic Core Facility & Custom Surgical Services is to produce transgenic mice and provide experimental animal

transgenic - Definitions from Dictionary.com
Of, relating to, or being an organism whose genome has been altered by the transfer of a gene or genes from another species or breed: transgenic mice; transgenic plants. Of or

Mice, Transgenic
Vertebrates [B02] Mammals [B02.649] Rodentia [B02.649.865] Muridae [B02.649.865.635] Mice [B02.649.865.635.500] Mice, Congenic [B02.649.865.635.500.100]

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Why Hillary Clinton Lost Black Star News, NY - 11 Jun 2008 With the click of a mouse, they would send in another $50. But the Clinton campaign continued to focus on big donor funding. The campaign used the Internet …

Nuevolution Announces Drug Discovery Alliance With Lexicon … - Earthtimes (press release)

Nuevolution Announces Drug Discovery Alliance With Lexicon … Earthtimes (press release), UK - 10 Jun 2008 … company explored the physiological and behavioral function for nearly 5000 human genes by studying the corresponding mouse genes in knockout animals. …

Study hints at milk thistle's heart health benefits - NutraIngredients.com

Study hints at milk thistle's heart health benefits NutraIngredients.com, France - 12 Jun 2008 … to determine the atheroprotective effect of silymarin in vivo using an atherosclerosis-prone apolipoprotein E or LDL receptor knockout mouse model. …

Unexpected Finding Of Molecule's Dual Role In Mice May Open New … - Science Daily (press release)

Unexpected Finding Of Molecule's Dual Role In Mice May Open New … Science Daily (press release) - 12 Jun 2008 Lee and colleagues developed a mouse model in which XBP1 functioned normally during fetal development but could be inactivated at will in the adult. …

NextBio Life Science Search Engine Advances Systems Biology … - Business Wire (press release)

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Show Review: REM at the United Center, Chicago, June 6, 2008 - Riverfront Times

Show Review: REM at the United Center, Chicago, June 6, 2008 Riverfront Times, MO - 7 Jun 2008 After all, I was going to be inconsolable if I missed REM, Modest Mouse and the National in Chicago. As it turned out, I missed most of the National's set …

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GENERATION OF TRANSGENIC MICE A laboratory manual Llu s Montoliu (1993) Updated version (1995) Additional notes (1997) See the contents of this manual

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In the January 15th issue of G&D, a research team led by Dr. Richard Behringer at MD Anderson Cancer Center reports that they have successfully switched the mouse Prx1 gene regulatory element with the Prx1 gene regulatory region from a bat and

An Update on Transcription Factors in Asthma CME - Medscape News
Asthma is characterized by the increased expression of many proteins that contribute to a very complex inflammatory cascade. Among these proteins are cytokines, chemokines, adhesion molecules, enzymes, and receptors. For most of these proteins, their

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ROME - President Bush said Thursday in Rome that he strongly disagreed with a U.S. Supreme Court ruling that clears foreign terrorism suspects at Guantanamo Bay to challenge their detention in American civilian courts. Bush suggested new legislation may now be needed to keep the American people safe

Lakers lead by record 21 points after 1st quarter - Baltimore Sun
LOS ANGELES - The Los Angeles Lakers led the Boston Celtics 35-14 after the first quarter of Game 4 of the NBA finals on Thursday night — the biggest deficit after 12 minutes in the history of the league’s championship series. The previous record was a 36-16 lead that Los Angeles took in Game 6 of

Taiwan, China agree to exchange offices - Washington Post
In this photo released by China’s Xinhua news agency, Chen Yunlin, right, chairman of Chinese mainland’s Association for Relations Across the Taiwan Strait, shakes hands with Chiang Pin-kun, chairman of the Taiwan-based Straits Exchange Foundation, over a meeting table in Beijing, Thursday, June 12