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Military objective: less sleep, more fight
Houston Chronicle, United States - 23 Nov 2006
… With the help of gene-knockout technology, Lexicon is researching possible treatments for … of such things as the Internet, cell phones and the computer mouse. …
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Promising New Sleep Drug, Gaboxadol, Works In Distinct Way To … - Medical News Today (press release)
Scientists ponder 'the Lilliput effect' - Christian Science Monitor
Scientists ponder 'the Lilliput effect'
Christian Science Monitor, MA - 15 Nov 2006
… They include the knockout punches of volcanic activity and an asteroid strike … out of existence, the incidence of disease carried by deer- and mouse-borne ticks …
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Functional roles of muscarinic M(2) and M(3) receptors in mouse stomach motility: Studies with muscarinic receptor knockout mice.
Functional roles of muscarinic M(2) and M(3) receptors in mouse stomach motility: Studies with muscarinic receptor knockout mice.
Eur J Pharmacol. 2006 Oct 17;
Authors: Kitazawa T, Hashiba K, Cao J, Unno T, Komori SI, Yamada M, Wess J, Taneike T
Functional roles of muscarinic acetylcholine receptors in the regulation of mouse stomach motility were examined using mice genetically lacking muscarinic M(2) receptor and/or M(3) receptor and their corresponding wild-type (WT) mice. Single application of carbachol (1 nM-30 muM) produced concentration-dependent contraction in antral and fundus strips from muscarinic M(2) receptor knockout (M(2)R-KO) and M(3) receptor knockout (M(3)R-KO) mice but not in those from M(2) and M(3) receptors double knockout (M(2)/M(3)R-KO) mice. A comparison of the concentration-response curves with those for WT mice showed a significant decrease in the negative logarithm of EC(50) (pEC(50)) value (M(2)R-KO) or amplitude of maximum contraction (M(3)R-KO) in the muscarinic receptor-deficient mice. The tonic phase of carbachol-induced contraction was decreased in gastric strips from M(3)R-KO mice. Antagonistic affinity for 4-diphenylacetoxy-N-methyl-piperidine (4-DAMP) or 11-([2-[(diethylamino)methyl]-1-piperdinyl]acetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one (AF-DX116) indicated that the contractile responses in M(2)R-KO and M(3)R-KO mice were mediated by muscarinic M(3) and M(2) receptors, respectively. Electrical field stimulation (EFS, 0.5-32 Hz) elicited frequency-dependent contraction in physostigmine- and N(omega)-nitro-l-arginine methylester (l-NAME)-treated fundic and antral strips from M(2)R-KO and M(3)R-KO mice, but the cholinergic contractile components decreased significantly compared with those in WT mice. In gastric strips from M(2)/M(3)R-KO mice, cholinergic contractions elicited by EFS were not observed but atropine-resistant contractions were more conspicuous than those in gastric strips from WT mice. Gastric emptying in WT mice and that in M(2)/M(3)R-KO mice were comparable, suggesting that motor function of the stomach in the KO mice did not differ from that in the WT mice. The results indicate that both muscarinic M(2) and M(3) receptors but not other subtypes mediate carbachol- or EFS-induced contraction in the mouse stomach but that the contribution of each receptor to concentration-response relationships is distinguishable. Although there was impairment of nerve-mediated cholinergic responses in the stomach of KO mice, gastric emptying in KO mice was the same as that in WT mice probably due to the compensatory enhancement of the non-cholinergic contraction pathway.
PMID: 17113073 [PubMed - as supplied by publisher]
Parkinson's Mutation Stunts Neurons - Science Daily (press release)
Parkinson's Mutation Stunts Neurons
Science Daily (press release) - 27 Nov 2006
… "These cellular and animal models may … Scientists Develop Transgenic Mouse That Models Parkinson's, Related Disorders (February 21, 2000) — The first mouse …
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To figure out the role of the seven SIRT genes, both Guarente and Sinclair have engineered two sets of genetically altered mice. For each SIRT gene, one strain lacks the gene entirely and another makes extra amounts of the genes product.
AUGUST 2006
Hollywood, FL, August 31 As things heat up for the IBF Light Heavyweight Title fight between Glen Johnson and Clinton Woods, Johnson confronts Woods at todays press conference in Bolton, England regarding comments that Woods apparently made in reference to knocking Johnson out in the sixth round of their upcoming …
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… for BM formation, as LAMC1-knockout mouse embryos cannot produce BM structures … it was reported that the knockout mouse of type IV collagen 1 and …
Knockout Mouse May Lead to Major Understanding of Human Kidney Disorder
nephmice … “Knockout” Mouse May Lead To Major Understanding of Human Kidney Disorder. August 30, 1999 … applications of “gene knockout” technology to date. …
Wikipedia: Gene knockout
A gene knockout is a genetically engineered organism that … It has been suggested that Knockout mouse be merged into this article or section. ( Discuss) …
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Mouse Mutagenesis Projects - Has Your Gene Been Knocked Out? International Gene Trap Consortium; Baygenomics; Sanger Institute Genetrap Resource; Baylor Mouse Mutagenesis Center for Developmental
TRANSGENIC MOUSE FACILITY
DIETMAR J. KAPPES, Ph.D., Associate Member, Director. JUDITH L. MORGAN, B.S., Manager. ANGELA V. EDWARDS, B.S., Scientific Technician . The Transgenic Mouse Facility produces transgenic and gene
Big Bench Software | Mouse Genetics Database | Transgenic Mouse Colony
Big Bench Mouse — Transgenic mouse colony software. Networkable colony-management database software TRANSGENIC MOUSE COLONY SOFTWARE. Welcome to the home of Big Bench Mouse — the complete colony
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USA Today - 16 hours agoBritish researchers said today that taking folic acid supplements may reduce the risk of heart attacks, Reuters reports. "The evidence is very persuasive" that folic acid can "lower your risk of heart attack …
Massachusetts Governor Sues to Compel Vote on Same-Sex Marriage …
New York Times - 5 hours agoBy KATIE ZEZIMA. BOSTON, Nov. 24 - Gov. Mitt Romney filed a lawsuit Friday asking the state s highest court to order the legislature to vote on a constitutional amendment banning same-sex marriage or to …
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Chop off a salamander’s leg and a brand new one will sprout in no time. But most animals have lost the ability to replace missing limbs. Now, a research team at the Salk Institute for Biological Studies has been able to regenerate a wing in a chick embryo — a species not known to be able to regrow limbs — suggesting that the potential for such regeneration exists innately in all vertebrates,
Prion disease found lurking in deer muscle
North American hunters could be at risk from eating deer and elk with chronic wasting disease
ITI Life Sciences Generates First Commercial Licence
ITI Life Sciences is pleased to announce that it has reached its first commercial milestone with the grant of a licence to CXR Biosciences (Dundee, Scotland) and Artemis Pharmaceuticals (Cologne, Germany) to use new technology generated in its R&D programme developing new predictive transgenic models for drug discovery and development
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Serves as a centralized resource for the production of transgenic and gene-targeted mice for Purdue investigators.
Transgenic Mice Gene-Targeting and Gene Knock-Out services - Center
CFG provides transgenic mouse production of gene targeted mice technologies for in vivo gene Equipment | Transgenic Mouse Production | Production of Gene Targeted Mice
Transgenic Mouse Production
4135 Neuroscience Research Building Phone: 919-843-9125: CB# 7264 Fax: 919-843-7237: Chapel Hill, NC 7264 Director:
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The Age, Australia - Oct 26, 2006… to use it to improve a few special photos or to create a knockout first impression … for $37, which lets you do the same thing with a few clicks of the mouse. …
Scientists ponder 'the Lilliput effect'
Christian Science Monitor, MA - Nov 15, 2006… They include the knockout punches of volcanic activity and an asteroid strike … out of existence, the incidence of disease carried by deer- and mouse-borne ticks …
Silver Lining
National Review Online, NY - Oct 20, 2006… Moreover and much more significantly Silver fails to mention that the knockout procedure involves first knocking out a specific gene in mouse stem cells …
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Coordinating Center for Rodent Genetics at National Institute of … the NIH with access to 251 knockout mouse lines and phenotypic data about each line. …
Knockout mice
The inactivation of a specific gene in a mouse. … Knockout mouse models are widely used to study human diseases caused by the loss …
The Knockout Mouse Project - Nature Genetics
The Comprehensive Knockout Mouse Project Consortium: Christopher P Austin1, … Mouse knockout technology provides a powerful means of elucidating gene function …
