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DIETMAR J. KAPPES, Ph.D., Associate Member, Director JUDITH L. MORGAN, B.S., Manager ANGELA V. EDWARDS, B.S., Scientific Technician . The Transgenic Mouse Facility produces transgenic and gene
Welcome to the Transgenic Core Facility
Services include transgenic mouse production by microinjection of oocytes, gene targeting in ES cells, generation of ES cell chimeras, and embryo cryopreservation.
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Production of Transgenic and Knockout Mouse; Mouse Genomics. Announcing an intensive 7-day course designed for investigators to acquire a
Mouse Knockout & Mutation Database
A fully searchable database of phenotypic information related to knockouts and classical mutations in mice. Requires subscription.
knockout mouse
7 Sept 2007 - the Red Horse Tavern (formerly Maxwell’s), Middleburg, VA; 9:30pm; no cover 14 Sept 2007 - Stonewall’s Tavern, Lansdowne Resort, Leesburg, VA; 9pm no cover
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Intellect Neurosciences, Inc. and CHDI, Inc. Enter Into Compound …
CNNMoney.com - Preclinical studies using transgenic mouse models have provided evidence that OXIGON(TM) has the potential to reduce brain amyloid burden and improve … |
Shinya Yamanaka, LK Whittier Foundation Investigator, Gladstone … - Nature.com (subscription)
 Nature.com (subscription) |
Shinya Yamanaka, LK Whittier Foundation Investigator, Gladstone …
Nature.com (subscription), UK - In 1993, he took a postdoctoral position at the Gladstone to work on knockout mice. "He exemplified qualities that often yield success in biology," says … |
Full Text - Science Magazine (subscription)
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Full Text
Science Magazine (subscription) - Very few papers reporting such severe experiments included information on refinement measures: Out of 14 survival studies of transgenic animals with a … |
Red tape forces scientist to take tests to US - Times Online
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Red tape forces scientist to take tests to US
Times Online, UK - While the creation of transgenic animals usually involves manipulating early embryos, Atazoa is instead altering the testes of adult male pigs so they … |
US set for humanised organ tests - Financial Times
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US set for humanised organ tests
Financial Times, UK - … using the genetically modified male pigs to sire young, ruling that breeding from transgenic farm animals would breach a European Union directive. … |
GTC Biotherapeutics to Webcast Corporate Presentation at the G5 … - Business Wire (press release)
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GTC Biotherapeutics to Webcast Corporate Presentation at the G5 …
Business Wire (press release), CA - GTC Biotherapeutics develops, produces, and commercializes therapeutic proteins through transgenic animal technology. ATryn , GTC s recombinant form of … |
Gene 'knock-out' mouse model gives molecular clues to breast cancer - NewKerala.com
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Gene 'knock-out' mouse model gives molecular clues to breast cancer
NewKerala.com, India - US scientists at the National Institutes of Health (NIH) had developed a standard oestrogen receptor (ER) gene knock out mouse model a decade ago, … |
Mice Thrive Missing Ancient DNA Sequences - Science Daily (press release)
 Science Daily (press release) |
Mice Thrive Missing Ancient DNA Sequences
Science Daily (press release) - Using standard mouse genetic-engineering techniques, the researchers prepared four lines of knockout mice, each type lacking one of the chosen … |
Winston blames red tape for move to US - Independent
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Winston blames red tape for move to US
Independent, UK - … a male pig's sperm cells so that the animals could then take part in a breeding programme to produce "transgenic" pigs with humanised organs which could … |
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Science Daily - SAPAP3 knockout mouse has a raw bald patch on its face from compulsive grooming behavior. (Credit: Guoping Feng, Ph.D., Duke University)
Under the Influence?
Slate - Every one of these BRCA1 “knockout” mice goes on to develop breast cancer before 9 months of age. Findings: A research group Not a single mifepristone-treated mouse developed breast cancer. Results this clear and dramatic are rare in science.
Animal Biotechnology - Technologies, Markets and Companies
BioPortfolio - A comparison of gene knockout and transgenic techniques 54 Table 2 4: Examples of transgenic mouse models of non-neoplastic human diseases 55 Table 2 5: Companies involved in xenotransplantation 62 Table 3 1: Diseases of dairy cattle 63 Table 3 2
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Winston blames red tape for move to US
Independent, UK - … a male pig's sperm cells so that the animals could then take part in a breeding programme to produce "transgenic" pigs with humanised organs which could … |
Mice Stressed In Simulated Weightlessness Show Organ Atrophy - Science Daily (press release)
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Mice Stressed In Simulated Weightlessness Show Organ Atrophy
Science Daily (press release) - This research was made possible by the creation at Rutgers of a mouse unable to make OPN (a "knock-out" mouse). Studies with this Rutgers mouse have … |
Critical Path Items for Year-End 2007 Highlighted in Presentation … - CNNMoney.com
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Critical Path Items for Year-End 2007 Highlighted in Presentation …
CNNMoney.com - … "Next week we are set to launch the first in a series of Apo E knockout mouse studies to demonstrate the effectiveness of our synthetic HDL candidate, … |
Full Text - Science Magazine (subscription)
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Full Text
Science Magazine (subscription) - Very few papers reporting such severe experiments included information on refinement measures: Out of 14 survival studies of transgenic animals with a … |
Mice Thrive Missing Ancient DNA Sequences - Science Daily (press release)
Science Daily (press release) |
Mice Thrive Missing Ancient DNA Sequences
Science Daily (press release) - Using standard mouse genetic-engineering techniques, the researchers prepared four lines of knockout mice, each type lacking one of the chosen … |
Gene knockout extends life of mice with ALS - Nature.com (subscription)
 Nature.com (subscription) |
Gene knockout extends life of mice with ALS
Nature.com (subscription), UK - Knocking out a single gene nearly doubles the lifespan of mice with the animal model of Lou Gehrig's disease, suggesting that the gene may one day become a … |
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Science Daily (press release) |
Mice Thrive Missing Ancient DNA Sequences
Science Daily (press release) - Using standard mouse genetic-engineering techniques, the researchers prepared four lines of knockout mice, each type lacking one of the chosen … |
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News Brief
The Gateway, Canada - Although it s very rare for humans to lack a gene, it was important Casey used knockout mice mice lacking Scl4a3 to find out what the gene s function was. … |
GTC Biotherapeutics to Webcast Corporate Presentation at the G5 … - Business Wire (press release)
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GTC Biotherapeutics to Webcast Corporate Presentation at the G5 …
Business Wire (press release), CA - GTC Biotherapeutics develops, produces, and commercializes therapeutic proteins through transgenic animal technology. ATryn , GTC s recombinant form of … |
Red tape 'hits transplant study' - The Press Association
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Red tape 'hits transplant study'
The Press Association - "If you don't make these animals within six to nine months you lose the possibility, probably, of making a transgenic animal," he said. … |
Endothelial and epithelial signaling in the lung - AJP-Lung Physiology (subscription)
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Endothelial and epithelial signaling in the lung
AJP-Lung Physiology (subscription) - For this reason, they created double-knockout mice formed from a global deletion of Cx40 and a conditional deletion of Cx43 from the vascular endothelial … |
US set for humanised organ tests - Financial Times
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US set for humanised organ tests
Financial Times, UK - … using the genetically modified male pigs to sire young, ruling that breeding from transgenic farm animals would breach a European Union directive. … |
Altered olivocerebellar activity patterns in the connexin36 knockout mouse.
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Related Articles |
Altered olivocerebellar activity patterns in the connexin36 knockout mouse.
Cerebellum. 2007 Feb 28;:1-13
Authors: Marshall SP, van der Giessen RS, de Zeeuw CI, Lang EJ
The inferior olive (IO) has among the highest densities of neuronal gap junctions in the nervous system. These gap junctions are proposed to be the underlying mechanism for generating synchronous Purkinje cell complex spike (CS) activity. Gap junctions between neurons are formed mostly by connexin36 proteins. Thus, the connexin36 knockout (Cx36KO) mouse provides an opportunity to test whether gap junction coupling between IO neurons is the basis of CS synchrony. Multiple electrode recordings of crus 2 CSs were obtained from wildtype (Wt) and Cx36KO mice. Wts showed statistically significant levels of CS synchrony, with the same spatial distribution as has been reported for other species: high CS synchrony levels occurred mostly among Purkinje cells within the same parasagittally-oriented cortical strip. In contrast, in Cx36KOs, synchrony was at chance levels and had no preferential spatial orientation, supporting the gap junction hypothesis. CS firing rates for Cx36KOs were significantly lower than for Wts, suggesting that electrical coupling is an important determinant of IO excitability. Rhythmic CS activity was present in both Wt and Cx36KOs, suggesting that individual IO cells can act as intrinsic oscillators. In addition, the climbing fiber reflex was absent in the Cx36KOs, validating its use as a tool for assessing electrical coupling of IO neurons. Zebrin II staining and anterograde tracing showed that cerebellar cortical organization and the topography of the olivocerebellar projection are normal in the Cx36KO. Thus, the differences in CS activity between Wts and Cx36KOs likely reflect the loss of electrical coupling of IO cells.
PMID: 17853112 [PubMed - as supplied by publisher]
Gene 'knock-out' mouse model gives molecular clues to breast cancer - NewKerala.com
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Gene 'knock-out' mouse model gives molecular clues to breast cancer
NewKerala.com, India - US scientists at the National Institutes of Health (NIH) had developed a standard oestrogen receptor (ER) gene knock out mouse model a decade ago, … |
New 'Knock-out' Gene Model Provides Molecular Clues To Breast Cancer - Science Daily (press release)
 Science Daily (press release) |
New 'Knock-out' Gene Model Provides Molecular Clues To Breast Cancer
Science Daily (press release) - Yuxin Feng, David Manka, PhD, and Sohaib Khan, PhD, have developed a estrogen receptor gene knock-out mouse model. (Credit: Image courtesy of University of … |
Socially Awkward Mice Are Apt Models for Autism Research - MedPage Today
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Socially Awkward Mice Are Apt Models for Autism Research
MedPage Today, NJ - The investigators also bred a line of neuroligin-3 knockout mice for comparison purposes. They found that both murine strains appeared to be physically … |
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… and too expensive for most labs to establish their own transgenic mouse facility. … Transgenic Core overcomes these hurdles by offering transgenic mouse …
Mouse Genome Project
Projects include creation of a physical map for mouse chromosome 11 based on data from BAC and YAC mapping, fingerprint and BAC end sequences, and more.
Charles River Labs- Laboratory Animals: Transgenic Mouse Models
Transgenic Models. Animal Creation. On-line Literature … of 900 Deltagen knockout mouse lines. Immortomouse Hemizygous … Transgenic …
Transgenic / Gene Targeting Facility
Transgenic, Transgenic Mouse Production, ES Cells, Electroporation, Pronuclear … Pipette, Mice, Mouse, Chimera, Chimeric, Microforge, … GFP Mouse …
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Bay Weekly - There will be Irish jigs, unrestrained drinking of foamy Irish suds, kindly Irish Catholic priests doling out pithy nuggets of advice and maybe some Irish little people, leprechauns dressed in green hats with buckles. At the least, we should expect a
Preclinical Study Links Gene To Brain Aneurysm Formation
Science Daily - The UC-led team analyzed 30 female mice bred to suppress (knock out) one of three genes and molecular pathways associated with vascular disease: inducible nitric oxide synthase (NOS-2), endothelial nitric oxide synthase (NOS-3) or the plasminogen
Microplasmin, a novel neuroprotective thrombolytic agent for the
BioPortfolio - This group has developed a complete panel of knock-out mice which contain genetic deletions in each of the components of the coagulation cascade in order to investigate the role that key thrombolytic molecules play in the
TGX-mAbFVIII-1, a type II monoclonal antibody to Factor VIII for
BioPortfolio - Knock out mice devoid of factor VIII invariably died from uncontrolled hemorrhage following surgical intervention. In dramatic contrast, blocking exogenous factor VIII by TGX-mAbFVIII-1 was not associated with excessive bleeding
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A knockout mouse is a genetically engineered mouse one or more of whose genes have been made inoperable through a gene knockout. Knockout is a route to learning about a gene that has been sequenced
Lexicon Pharmaceuticals: Drug Discovery: OmniBank: OmniBank e-Biology
Biology program has been designed to accelerate academic and non-profit research of human gene function by offering academic and non-profit researchers the opportunity to purchase knockout mouse lines
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Mice Stressed In Simulated Weightlessness Show Organ Atrophy
Science Daily (press release) - This research was made possible by the creation at Rutgers of a mouse unable to make OPN (a "knock-out" mouse). Studies with this Rutgers mouse have … |
Out of Rockville and Laurel - American Veterinary Medical Association
 American Veterinary Medical Association |
Out of Rockville and Laurel
American Veterinary Medical Association, IL - … more and more is biotechnology, and that's going to encompass a lot of the scenarios that will come from cloning and, potentially, transgenic animals. … |
Vegetarian Capsules: Biorefining Of Corn Brings Gelatin Production … - Science Daily (press release)
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Vegetarian Capsules: Biorefining Of Corn Brings Gelatin Production …
Science Daily (press release) - "Protein production from transgenic plants is a challenging process, with potential pitfalls all along the way," Glatz says. "It is important to develop … |
Born to run: Gene clue to athletic endurance - AFP
 AFP |
Born to run: Gene clue to athletic endurance
AFP - The easy winners in this endurance test were the knockout mice, which were able to run on average a third further than their counterparts. … |
Latest transgenic rabbit-milk drug results - Checkbiotech.org (press release)
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Latest transgenic rabbit-milk drug results
Checkbiotech.org (press release), Switzerland - Only one such transgenic animal-derived drug is currently available on the market, GTC Biotherapeutics' goat-derived ATryn - which was approved last year as … |
Biotech to bring home the bacon? - Truth about Trade & Technology
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Biotech to bring home the bacon?
Truth about Trade & Technology, IA - Animals to be raised for food are propagated in conventional breeding programs. The only currently marketed transgenic animal is an ornamental (aquarium) … |
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