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Knockout Mouse Forum - Discuss and post questions about knockout mice, transgenic mice and other transgenic animal models. Welcome to the Molecular Biology Forum forums. You

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Cholesterol drug strips staph of color, virulence Reuters - 14 hours ago "Once you knock out the enzyme, the bacteria still proliferates, but the immune system can kill it," he said. Other researchers discovered that three drugs …

Transgenic Goats to Serve Mankind - Russia-InfoCenter

Russia-InfoCenter

Transgenic Goats to Serve Mankind Russia-InfoCenter, Russia - 29 Jan 2008 The idea of transgenic animals producing human lactoferrin is not new it appeared about ten years ago. Scientists started with genetic engineering, …

Computer Biologist - Nature.com (subscription)

Computer Biologist Nature.com (subscription), UK - 7 Feb 2008 Recently large scale international projects have been started to knock out mouse genes in a systematic and coordinated manner. The High Throughput Gene …

Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development.

Related Articles

Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development.

Dev Dyn. 2008 Feb 8;

Authors: Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC

Epicardium and epicardium-derived cells have been shown to be necessary for myocardial differentiation. To elucidate the function of podoplanin in epicardial development and myocardial differentiation, we analyzed podoplanin knockout mouse embryos between embryonic day (E) 9.5 and E15.5 using immunohistochemical differentiation markers, morphometry, and three-dimensional reconstructions. Podoplanin null mice have an increased embryonic lethality, possibly of cardiac origin. Our study reveals impairment in the development of the proepicardial organ, epicardial adhesion, and spreading and migration of the epicardium-derived cells. Mutant embryos show a hypoplastic and perforated compact and septal myocardium, hypoplastic atrioventricular cushions resulting in atrioventricular valve abnormalities, as well as coronary artery abnormalities. The epicardial pathology is correlated with reduced epithelial-mesenchymal transformation caused by up-regulation of E-cadherin, normally down-regulated by podoplanin. Our results demonstrate a role for podoplanin in normal cardiac development based on epicardial-myocardial interaction. Abnormal epicardial differentiation and reduced epithelial-mesenchymal transformation result in deficient epicardium-derived cells leading to myocardial pathology and cardiac anomalies. Developmental Dynamics, 2008. (c) 2008 Wiley-Liss, Inc.

PMID: 18265012 [PubMed - as supplied by publisher]

GTC Biotherapeutics to Webcast Corporate Presentation at the 10th … - WELT ONLINE

GTC Biotherapeutics to Webcast Corporate Presentation at the 10th … WELT ONLINE, Germany - 6 Feb 2008 About GTC Biotherapeutics GTC Biotherapeutics develops, supplies, and commercializes therapeutic proteins produced through transgenic animal technology. …

R&D DIRECTOR (NEURODEGENERATION) - Nature.com (subscription)

R&D DIRECTOR (NEURODEGENERATION) Nature.com (subscription), UK - 23 hours ago He/she will develop new models of transgenic and knock-out mice using the target genes validated by the company. The candidate will have under his/her …

Knock-Out Mice Show Supercharged Immune Systems - MedPage Today

MedPage Today

Knock-Out Mice Show Supercharged Immune Systems MedPage Today, NJ - 13 Feb 2008 For instance, in wild-type mouse embryonic fibroblasts exposed to vesicular stomatitis virus, viral proteins were seen four hours after exposure. …

HRN Targeted Mutation Mouse - BioResearch Online (press release)

BioResearch Online (press release)

HRN Targeted Mutation Mouse BioResearch Online (press release), PA - 14 Feb 2008 Originally developed by Cancer Research UK and commercialized by CXR Biosciences, this conditional, targeted knockout of Por (cytochrome P450 reductase) in …

Body weight influenced by thousands of genes - innovations report

Body weight influenced by thousands of genes innovations report, Germany - 17 Jan 2008 Knockout mice are now standard tools in all mouse models of behavior and disease. In 60% of strains, knocking out a gene produces mice that are nonviable; …

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Act or perish, report warns African countries Africa Science News Service, Kenya - 14 Feb 2008 The report blames the current global controversies and power plays between the anti and pro transgenic groups as creating much uncertainty about a promising …

R&D DIRECTOR (NEURODEGENERATION) - Nature.com (subscription)

R&D DIRECTOR (NEURODEGENERATION) Nature.com (subscription), UK - 3 hours ago He/she will develop new models of transgenic and knock-out mice using the target genes validated by the company. The candidate will have under his/her …

HRN Targeted Mutation Mouse - BioResearch Online (press release)

BioResearch Online (press release)

HRN Targeted Mutation Mouse BioResearch Online (press release), PA - 14 Feb 2008 Originally developed by Cancer Research UK and commercialized by CXR Biosciences, this conditional, targeted knockout of Por (cytochrome P450 reductase) in …

NTU discovery may help cardiovascular, cancer experiments - Taipei Times

NTU discovery may help cardiovascular, cancer experiments Taipei Times, Taiwan - 30 Jan 2008 The knockout mouse technique has the greatest potential in the field. Three scientists were awarded the Nobel Prize for Medicine last year for producing the …

GTC Biotherapeutics to Webcast Corporate Presentation at the 10th … - WELT ONLINE

GTC Biotherapeutics to Webcast Corporate Presentation at the 10th … WELT ONLINE, Germany - 6 Feb 2008 About GTC Biotherapeutics GTC Biotherapeutics develops, supplies, and commercializes therapeutic proteins produced through transgenic animal technology. …

Zebrafish s fluorescent green blood vessels allow cancer … - Terre Haute Tribune Star

Zebrafish s fluorescent green blood vessels allow cancer … Terre Haute Tribune Star, IN - 13 Feb 2008 To do the same thing on a mouse, essentially a mouse knock-out experiment, you re probably looking at a year, which will cost lots of money and require …

Mice genetically modified to catch the common cold - Radio Netherlands

Mice genetically modified to catch the common cold Radio Netherlands, Netherlands - 5 Feb 2008 'Transgenic mice', to give them their official name, are therefore laboratory animals with a human gene built in. This makes it a mouse that responds to …

Computer Biologist - Nature.com (subscription)

Computer Biologist Nature.com (subscription), UK - 7 Feb 2008 Recently large scale international projects have been started to knock out mouse genes in a systematic and coordinated manner. The High Throughput Gene …

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WebWire - Using a mouse model of the disease, Greengard s team shows that side effects associated with repeated L-DOPA treatment rotational behavior and involuntary movements decreased in the p11-intact 6-OHDA-treated mice, but not in the p11 knockout

Gene `Knockout’ Wins Medical Nobel for 3 Scientists (Update6)
Bloomberg - More than 500 mouse models have been developed since the late 1980s, when Capecchi and Evans learned how to insert new At first, the scientists inactivated genes to determine what they were responsible for, prompting the terminology “knockout

Body Weight Influenced By Thousands Of Genes
Science Daily - To obtain an estimate of how many genes contribute to body weight, the Monell researchers surveyed the Jackson Laboratory Mouse Genome Database for information on body weights of knockout mouse strains. Knockout mice have had a specific gene

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New Study Claims 6000 Genes Responsible For Obesity AHN - 16 Jan 2008 The Monell researchers identified the 6000 genes by analyzing the body weights of knockout mouse strains at the Jackson Laboratory Mouse Genome Database. …

How free radicals make us old - Scientist

How free radicals make us old Scientist, UK - 5 hours ago Gaelle Laurent at the Curie Institute in Paris and colleagues created knockout mice missing gene that protects cells against oxidative stress, JunD. …

FDA downplays long-term impact of animal cloning - Canada.com

Canada.com

FDA downplays long-term impact of animal cloning Canada.com, Canada - 24 Jan 2008 Farm workers Ricardo Visconti (L) and Ruben Perez hold Jersey transgenic cows, four-year-old Pampa Victoria and two-year-old Pampa Argentina respectively, …

Is Old Age Memory Decline Reversible? - Scientific American

Is Old Age Memory Decline Reversible? Scientific American - 31 Jan 2008 Normal mice took about three days to make the connection, but Evans says the knockout mice were still on "a learning curve" six days into the experiment. …

NTU discovery may help cardiovascular, cancer experiments - Taipei Times

NTU discovery may help cardiovascular, cancer experiments Taipei Times, Taiwan - 30 Jan 2008 The knockout mouse technique has the greatest potential in the field. Three scientists were awarded the Nobel Prize for Medicine last year for producing the …

Newborn Brain Cells Modulate Learning And Memory - Science Daily (press release)

Newborn Brain Cells Modulate Learning And Memory Science Daily (press release) - 30 Jan 2008 "In the past, methods to knock out neurogenesis, such as radiation and mitotic inhibitors that block all cell division have been rather crude," he says. …

Gene therapy speeds transgenic animal production - In-PharmaTechnologist.com

Gene therapy speeds transgenic animal production In-PharmaTechnologist.com, UK - 12 hours ago Experts say these transgenic animals could cut the cost of insulin and other cancer-fighting proteins. Current methods of producing such animals involves …

Valent USA and Sumitomo Chemical File Complaints at ITC and in … - FOXBusiness

Valent USA and Sumitomo Chemical File Complaints at ITC and in … FOXBusiness - 1 Feb 2008 That patent "claims patent protection for controlling pests on transgenic useful plants with clothianidin, whereas the earlier '404 patent received patent …

A time of transition at the FDA Center for Veterinary Medicine - American Veterinary Medical Association

A time of transition at the FDA Center for Veterinary Medicine American Veterinary Medical Association, IL - 7 hours ago In a recent JAVMA News article, Drs. Dunham and Sundlof discussed how the center is studying areas ranging from pharmacogenomics to transgenic animals to …

Over 6000 genes influence body weight in mice - Thaindian.com

Over 6000 genes influence body weight in mice Thaindian.com, Thailand - 14 Jan 2008 During the study, the researchers surveyed the Jackson Laboratory Mouse Genome Database for information on body weights of knockout mouse strains. …