GTC Biotherapeutics to Webcast Corporate Presentation at the … - WELT ONLINE
-
GTC Biotherapeutics to Webcast Corporate Presentation at the …
WELT ONLINE, Germany - About GTC Biotherapeutics GTC Biotherapeutics develops, supplies, and commercializes therapeutic proteins produced through transgenic animal technology. … |
Biogen Start-up Escoublac Finds Link Between Bones and Obesity - TMCnet
Biogen Start-up Escoublac Finds Link Between Bones and Obesity
TMCnet - "We became convinced that bone was an endocrine-regulating organism because we noticed that when we generated a knockout of osteocalcin, the mice were fat," … |
Francis Collins, Carlos Brody, James Collins, Michael Eisen … - bio1nf0rm (subscription)
Francis Collins, Carlos Brody, James Collins, Michael Eisen …
bio1nf0rm (subscription), NY - He also guided a number of follow-up initiatives, such as the International HapMap Project, the Encyclopedia of DNA Elements, the Knockout Mouse Project, … |
| Related Articles |
Muscarinic Receptor Knockout Mice Confirm Involvement of M3 Receptor in Endothelium-dependent Vasodilatation in Mouse Arteries.
J Cardiovasc Pharmacol. 2008 May;51(5):505-512
Authors: B ny JL, Nguyen MN, Marino M, Matsui M
The aim of the study was to determine which cholinergic muscarinic receptor subtype is responsible for the endothelium-dependent vasodilatation evoked by acetylcholine (ACh) in mouse arteries. Endothelium-dependent relaxations were evaluated using isometric tension measurement of ring from femoral and aortic artery of M1, M2, and M3 knockout (KO) mice. Rings of femoral and aortic artery from M3 KO mice did not exhibit relaxation at the opposite of rings from M1+M2 KO and wild-type (WT) mice, which were relaxed by ACh. The proportion of endothelial cells responsive to ACh, as manifested by an increase in cytosolic free calcium ([Ca]i), was also observed on the intima of aorta wall in vitro by using laser line confocal microscopy. Of the cells from M3 KO mice and M1+M2 KO mice, 4% and 23%, respectively, responded to ACh in comparison with 20 % in WT mice. These results show that in the endothelium from femoral and aortic artery, the larger proportion of cells that express M3 receptor is responsible for the specificity of the M3 receptor subtype for endothelium-dependent relaxation caused by ACh.
PMID: 18460983 [PubMed - as supplied by publisher]
Elixir finds genetically altered mice may prove treatment goal for … - Bizjournals.com
Elixir finds genetically altered mice may prove treatment goal for …
Bizjournals.com, NC - Elixir Pharmaceuticals Inc. claims that specially engineered mice have proven that it is possible to treat type 2 diabetes or obesity by blocking a … |
New GE Animals a Threat to New Zealand's Export Reputation - Scoop.co.nz (press release)
New GE Animals a Threat to New Zealand's Export Reputation
Scoop.co.nz (press release), New Zealand - Transgenic experiments present real risks of creating unexpected effects that may include the creation of new diseases in animals as well as new harmful … |
Non-invasive measurements of exhaled NO and CO associated with …
7thSpace Interactive (press release), NY - Conclusions: These results are consistent with the ideas that: 1) ENO is associated with mouse strain and knockout differences in NO production and AR, … |